Gout Explained: How Purine Metabolism Causes High Uric Acid and What Medications Actually Work
Gout is caused by uric acid crystals forming in joints due to faulty purine metabolism. Allopurinol, febuxostat, and pegloticase are the main drugs used to lower uric acid long-term. Most patients don’t take enough allopurinol, leading to treatment failure. Proper dosing and monitoring are critical.
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