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Opioids and Antihistamines: Why Combining Them Can Be Deadly
Sergei Safrinskij 26 December 2025 1

Opioids and Antihistamines: Why Combining Them Can Be Deadly

Combining opioids with sedating antihistamines like Benadryl can cause life-threatening respiratory depression. Learn why this interaction is deadly, who's most at risk, and what safer alternatives exist.

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